Open Fetal Microneurosurgery for Intrauterine Spina Bifida Repair

<b><i>Objectives:</i></b> The aim of the study was to describe feasibility open fetal microneurosurgery for intrauterine spina bifida (SB) repair and compare perinatal outcomes with cases managed using classic surgery technique. <b><i>Methods:</i></b> In this study, we selected a cohort consecutive fetuses isolated SB referred our center in Queretaro, Mexico, during 3.5-year period (2016–2020). performed by either (6- 8-cm hysterotomy leakage amniotic fluid, which replaced before uterine closure) or microneurosurgery, is novel technique characterized 15- 20-mm diameter, reduced manipulation fixing back, maintenance normal fluid volume whole surgery. Perinatal operated were compared. <b><i>Results:</i></b> Intrauterine complete 3-layer correction successfully 60 (<i>n</i> = 13) 47). No significant differences observed gestational age (GA) at intervention (25.4 vs. 25.1 weeks, <i>p</i> 0.38) surgical times (107 120 min, 0.15) between both groups. group showed significantly lower rate oligohydramnios (0 15.4%, 0.01), preterm rupture membranes (19.0 53.8%, higher GA birth (35.1 32.7 0.03), delivery <34 weeks (21.4 61.5%, death (4.8 23.1%, 0.04) than During infant follow-up, hydrocephalus requiring ventriculoperitoneal shunting similar groups (7.5 20%, 0.24). All patients an intact site delivery. <b><i>Conclusion:</i></b> feasible associated better